Fig. 2
Anti-CCA activity and tumor volume (TV) progression (mm3) in CCA (CL6)-xenografted nude mice following initiation of treatment with K. galanga Linn. extract at high (1000 mg/kg body weight), medium (500 mg/kg body weight), and low (100 mg/kg body weight) dose levels versus the control groups (vehicle treated and 5-FU treated) during the investigation period. Treatment was started on day 7th after tumor transplant induction. Median survival time of the CCA-xenografted nude mice treated with the high dose extract [1000 mg/kg body weight: 62 (53.2–71.8) days] and 5-FU [59.0 (55.0–63.0) days] were significantly longer than the untreated control mice [49 (54.4–52.6) days]. Each data point is the median value of 6 tumors (from 3 male and 3 female mice) for each treatment group