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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice

Fig. 3

The effect of YKS and KST on ISO-induced attention deficit-like behavior in mice. The latency of each animal was recorded in the therapeutic (a) and preventive/delaying procedures (b) and pharmacological analysis of preventive/delaying effect (c). YKS and KST were administered orally at doses of 1523.6 and 2031.8 mg/kg/day, respectively, for 3–4 weeks before the test, and scoplamine (SCP: 0.1 mg/kg) was injected intraperitoneally 1 h before test. The number of each group is 23 (GH-water), 26 (ISO-water), 12 (ISO-YKS) and 12 (ISO-KST) in (a), 12, 12, 12 and 12 in (b), and 9, 11, 8, 8, 12 (ISO-YKS-SCP) and 11 (ISO-KST-SCP) in (c). Each data column represents the mean ± S.E.M. *p < 0.05, **p < 0.01 compared with GH mice. # p < 0.05, ## p < 0.01 compared with the saline-administered ISO group

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