Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

Table 1 Inhibitory effect of crude ethanol extract (CEE) from S. orientalis on serum uric acid levels in rats

Group treatment	Dose (mg/kg)	Number	Serum uric acid levels (μmol/L)	Inhibition (%)
Normal			116.17 ± 8.71
Control		8	218.66 ± 16.82^##
CEE	300	8	174.49 ± 12.31	20.2
	600	8	159.16 ± 16.36*	27.2
	1200	8	158.18 ± 14.07*	27.7
Allopurinol	10	8	101.69 ± 15.98**	53.5

Hyperuricemic rats were induced by a potassium oxonate injection 1 h before the last drug administration. The CEE at 300, 600 and 1200 mg/kg and allopurinol at 10 mg/kg were orally administrated once a day for five consecutive days. The control and normal groups were orally administered with 0.5% CMC-Na. The serum uric acid levels of rats were measured by the phosphotungstic acid method. Values are displayed as mean ± SEM
*p < 0.05, **p < 0.01 vs. hyperuricemic rats (control);
#p < 0.05, ##p < 0.01 vs. normal rats

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