Fraction/Compound | Antiplasmodial activity IC50 ± SD (μg/mL) | Cytotoxicity CC50 ± SD (μg/mL) | Selectivity index (SI) against IPC-4912 | ||
---|---|---|---|---|---|
3D7 | Dd2 | IPC 4912 Mondolkiri Cambodia 2011 | CC50 on LLC-MK2 (μg/mL ± SD) | ||
1:1 DCM/EtoAC fraction | 4.08 ± 2.87 | 9.33 ± 2.09 | 2.99 ± 4.84 | 76.09 ± 8.44 | 25.4 |
Sub-fraction 1 (Semi-pure) | 3.06 ± 0.80 | 2.26 ± 0.97 | 5.12 ± 1.0 | > 200 | >39.1 |
Norcaesalpin D compound | 0.98 ± 0.03 (2.83 μM) | 1.85 ± 0.05 (5.35 μM) | 2.13 ± 0.7 (6.16 μM) | > 200 (>578 μM) | >93.9 |
QN | 0.052 ± 0.01 | 0.06 ± 0.01 | 0.068 ± 0.005 |