Skip to main content

Table 5 MGIT-DST of MDR-Mtb with Exo-MS alone and in combination with INH and RIF

From: Preliminary evaluation of anti-tuberculosis potential of siderophores against drug-resistant Mycobacterium tuberculosis by mycobacteria growth indicator tube-drug sensitivity test

MDR- Mtb (INH R + RIF R) Isolate

Exo-MS (mg/mL)

Exo-MS (mg/mL) + INH 0.1 μg/mL

Exo-MS (mg/mL) + RIF 1.0 μg/mL

Ferric citrate + Exo-MS (mg/mL)

0.125

0.25

0.5

0.125

0.25

0.5

0.125

0.25

0.5

0.5

1

400

400

400

400

400

400

400

400

400

400

2

400

400

0

400

400

0

400

400

0

400

3

400

400

0

400

400

0

400

400

12

400

4

400

400

400

400

400

400

400

400

400

400

5

400

400

253

400

400

105

400

400

131

400

INFERENCE

R

R

S n = 2

R

R

S n = 2

R

R

S n = 2

R

  1. GU value of GC for all five isolates was 400. GU value in INH- and RIF-containing medium for all isolates was also 400. R resistant, S Susceptible. If the GU value of the drug-containing tube is ≥100, the interpretation is Resistant by the MGIT instrument. If the GU value of the drug tube is <100, the interpretation is Susceptible (n = no. of isolates susceptible)
  2. Inhibitory effect of Exo-MS, Exo-MS + INH, Exo-MS + RIF on five clinical isolates of MDR-Mtb (INH-, RIF- and PZA-resistant). The medium used was Middlebrook 7H9 broth, pH = 7 incubated at 37 °C for14 days in the MGIT instrument