Table 6 EC50 values of the test materials against force and rate of contractions in guinea-pig atria
Test materials | Force (inhibition) with resultant EC50 values with 95% confidence interval/Mean ± SEM, n = 3–7 | Rate (inhibition) with resultant EC50values, n = 3–7 |
|---|---|---|
POL4.Cr | 1.28 mg/ml (1.08–1.52) | 1.22 mg/ml (0.70–2.15) |
Verapamil | 0.14 mg/ml (0.11–0.83) | 0.19 mg/ml (0.15–0.24) |
Ci.Cr | 4.18 mg/ml (3.92–4.46) | 3.16 mg/ml (2.95–3.39) |
Gs.Cr | 2.47 mg/ml (2.24–2.72) | 3.16 mg/ml (3.03–3.30) |
Ns.Cr | Mild cardiac stimulation (110.66 ± 2.33%) at 0.03 mg/ml followed by inhibition at 1–10 mg/ml. | 2.47 mg/ml (2.06–2.95) |
Tfg.Cr | 3.65 mg/ml (3.21–4.16) | 3.516 mg/ml (3.23–3.82) |