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Table 2 Relative organ weight for mice treated with UP601 in HFH-induced mouse obesity model

From: UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss

Group

Liver (%)

Fat deposit (%)

Epididymal

Retroperitoneal

Peri-Renal

Mesenteric

Total

NC

3.39 ± 1.47

1.75 ± 0.33‡

0.44 ± 0.14‡

0.24 ± 0.10‡

0.81 ± 0.15‡

3.22 ± 0.67‡

HFF

3.17 ± 0.47

6.93 ± 1.06

1.69 ± 0.30

0.99 ± 0.20

2.76 ± 0.97

12.36 ± 1.17

ORI (40)

3.21 ± 0.12

5.75 ± 1.59

1.41 ± 0.38

0.65 ± 0.17†

1.58 ± 0.64*

9.38 ± 2.63*

UP601 (300)

2.83 ± 0.14

6.82 ± 0.64

1.68 ± 0.14

0.82 ± 0.17

1.99 ± 0.48

11.31 ± 0.92

UP601 (450)

2.96 ± 0.16

5.31 ± 1.04*

1.53 ± 0.29

0.55 ± 0.12‡

1.38 ± 0.24

8.76 ± 1.54‡

UP601 (600)

2.99 ± 0.17

1.57 ± 1.57†

0.42 ± 0.42*

0.12 ± 0.12‡

0.30 ± 0.30†

2.41 ± 2.41‡

  1. HFF-induced obese C57BL/6J mice were treated with UP601 at oral doses of 300, 450 and 600 mg/kg for 7-weeks. Orlistat (ORI) at 40 mg/kg was used as a reference compound. Tissue collections were carried out at necropsy. NC Normal control + vehicle, HFF HFF + Vehicle, ORI HFF + orlistat, UP601 HFF + indicated concentrations of UP601 (mg/kg). * P ≤ 0.05 compared to HFF group; † P ≤ 0.001 compared to HFF group; ‡ P ≤ 0.0001 compared to HFF group