Table 4 PK parameters of AA I in rats after oral administration of AF and HAF (mean ± SD, n = 6)

Dose

mg/kg

3.0

3.0

8.0

8.0

15.0

15.0

C _max

μg/L

1704.0 ± 570.8

1072.3 ± 223.1*

3823.8 ± 450.3

2002.5 ± 312.8*

5891.3 ± 425.5

3474.3 ± 352.3*

T_max

h

0.50 ± 0.09

0.39 ± 0.08

0.56 ± 0.09

0.42 ± 0.08

0.69 ± 0.10

0.47 ± 0.08

t _1/2z

h

3.50 ± 0.50

3.22 ± 0.46

5.58 ± 0.65

4.72 ± 0.52

5.46 ± 0.53

5.32 ± 0.54

AUC_(0-∞)

μg/L · h

6080.4 ± 1263.2

5227.0 ± 895.6*

12770.7 ± 1857.5

8985.3 ± 1784.9*

26844.6 ± 3264.7

11782.2 ± 1769.2*

V_z/F

L/kg

2.85 ± 0.15

2.75 ± 0.24

5.40 ± 0.48

4.58 ± 0.37

7.13 ± 0.57

5.53 ± 0.52

CL_z/F

L/h/kg

0.57 ± 0.06

0.59 ± 0.08

0.65 ± 0.09

0.68 ± 0.07

0.87 ± 0.12

0.72 ± 0.08