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Table 2 Influence of the aqueous and methanol extracts of Piptadeniastrum africanum on haematological in CFA-induced arthritis in rats

From: Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

 

Dose (mg/kg)

Haemoglobin (g/dl)

RBC (million/μl)

Hematocrit (%)

WBC (109/L)

Platelet (109/L)

Healthy control

-

14.35 ± 0.45

7.37 ± 0.10

40.80 ± 2.50

7.45 ± 0.45

813.00 ± 40.00

Arthritic control

-

8.50 ± 0.20γ

3.99 ± 0.44β

26.75 ± 1.55α

13.25 ± 0.35γ

1815.00 ± 20.00γ

Indomethacin

5

11.60 ± 0.60a

6.05 ± 0.45

35.10 ± 2.20

10.00 ± 0.10b

1074.00 ± 26.00αc

Aqueous extract

200

12.05 ± 0.15a

5.90 ± 0.07

34.60 ± 0.90

8.80 ± 0.80b

1110.00 ± 21.00αc

400

12.15 ± 0.65a

6.53 ± 0.13a

36.85 ± 1.05a

8.40 ± 0.30b

1043.50 ± 4.50c

Methanol extract

200

12.15 ± 0.35a

6.13 ± 0.57

35.00 ± 3.00

10.85 ± 0.85α

1134.00 ± 45.00βc

400

12.45 ± 0.45a

6.89 ± 0.33a

38.60 ± 2.00a

8.85 ± 0.15b

919.00 ± 84.00c

  1. CFA complete Freund’s adjuvant, RBC red blood cell, WBC white blood cell, Hb haemoglobin, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration. Each value represents the mean ± ESM of six animals. α P < 0.05; β P < 0.01; γ P < 0.001 statistically significant compared to Healthy control. Each value represents the mean ± ESM of 6 animals. a P < 0.05; b P < 0.01; c P < 0.001 statistically significant compared to Arthritic control