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Table 1 IC50 value of aqueous and methanol extracts of Piptadeniastrum africanum on human whole blood evaluated by luminol and/or lucigenin amplified chemiluminescence

From: Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

 

Oxidative burst (IC50 μg/ml)

T-cells proliferation (IC50 μg/ml)

Cytotoxicity on 3T3 Cells (IC50 μg/ml)

Luminol and Zymosan

Lucigenin and PMA

  

WB

PMNs

MQ

WB

PMNs

MQ

  

Aqueous extract

10.04 ± 0.31

8.68 ± 0.52

11.64 ± 0.29

8.59 ± 0.12

5.74 ± 0.38

11.85 ± 0.36

29.30 ± 0.36

78.60 ± 0.35

Methanol extract

4.02 ± 0.10

2.29 ± 0.10

2.85 ± 0.12

4.89 ± 0.28

2.96 ± 0.07

2.80 ± 0.02

<1

6.13 ± 0.25

Ibuprofen

13.00 ± 0.30

12.97 ± 0.23

13.93 ± 0.52

13.73 ± 0.58

13.69 ± 0.61

14.30 ± 0.49

-

-

Prednisolone

-

-

-

-

-

-

<3.1

-

Cyclohexamide

-

-

-

-

-

-

-

0.1 ± 0.13

  1. The IC50 values are presented as mean ± SD of triplicates. Where WB whole blood, PMNs polymorphonuclear leukocytes, MQ mice peritoneal macrophages