Fig. 6

Combination of TAM with BD regulates expression of apoptosis and TAM resistance related proteins in human breast tumors. Animal experiments were performed as described in Fig. 3. Paraffin-embedded tumor tissue sections were analyzed by immunohistochemistry using antibodies against BRAF, p21, Bcl-2 and Fibronectin (FN). Representative localization and intensity of immunoreactivities against all primary antibodies are shown. Immunohistochemical quantification of BRAF, p21, Bcl-2 and FN were determined as described in Materials and Methods. Statistical analysis by ANOVA and Holm-Sidak. Different letters above bars indicate significant differences P < 0.05. The graphical data represent mean (white dotted line) +/− SD, triangles represent outliers. (n = 10)