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Table 1 Cytotoxicity and direct antiviral activity against HSV-2 of the 50% ethanolic extract prepared from fruits of T. chebula, chebulagic acid, chebulinic acids and acyclovir in Vero cells

From: Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids

Test compounds

aCC50 (μg/ml)

bIC50 (μg/ml)

T. chebula 50% ethanolic extract

409.71 ± 47.70

0.01 ± 0.0002

Chebulagic acid

>200c

1.41 ± 0.51

Chebulinic acid

>200c

0.06 ± 0.002

Acyclovir

351.85 ± 48.80

29.04 ± 1.04

  1. Values in this table represent the mean ± SE of four independent experiments performed in duplicate
  2. aCC50 was the concentration that showed viability of 50% of the Vero cells
  3. bIC50 was the concentration that inhibited 50% of HSV-2 activity in direct anti- viral activity assay using Vero cells as host
  4. c > 95% cells were viable at 200 μg/ml