|
Drugs
|
Doses
mg/kg
|
1st week
(ml/rat/week)
|
2nd week
(ml/rat/week)
|
3rd week
(ml/rat/week)
|
4th week
(ml/rat/week)
|
---|
|
HC + Distilled water
|
0
|
116.12 ± 1.21
|
137.12 ± 1.12
|
142.10 ± 1.22
|
146.21 ± 1.32
|
During treatment
|
HC + Extract
|
240
|
179.04 ± 1.23*a
|
158.32 ± 1.16*a
|
160.24 ± 1.14*a
|
179.31 ± 1.22*a
|
320
|
139.43 ± 1.22**a
|
200.31 ± 1.32**a
|
215.12 ± 1.32**a
|
236.83 ± 1.11**a
|
400
|
178.43 ± 2.33**a
|
239.25 ± 1.67**a
|
265.27 ± 2.37**a
|
289.66 ± 1.23**a
|
HC + Atorvastatin
|
1
|
145.95 ± 1.12
|
164.75 ± 1.13
|
174.15 ± 1.13
|
166.64 ± 1.12
|
After treatment
|
HC + Extract
|
240
|
86.33 ± 1.17**b
|
88.44 ± 1.17**b
|
89.22 ± 1.17**b
|
89.10 ± .1.20**b
|
320
|
95.32 ± 1.66**b
|
86.22 ± 1.16**b
|
97.12 ± 1.77**b
|
98.44 ± 1.25**b
|
400
|
103.93 ± 1.11**b
|
99.77 ± 1.11**b
|
100.93 ± 1.01**b
|
101.65 ± 0.83**b
|
HC + Atorvastatin
|
1
|
141.85 ± 3.72
|
162.75 ± 2.76
|
160.75 ± 3.78
|
166.69 ± 1.03
|
- Values are means ± S.E.M., n = 5, *P < 0.05, **P < 0.01 significant difference compared to HC+ Distilled water. HC Hypercholesterolemic rat; asignificant difference compared to HC+ Distilled water; bsignificant difference compared to animals previously treated with aqueous extract during the treatment at the same dose