Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Table 8 Effects of D. sissoo leave extract on involvement of cyclic guanosine monophosphate (cGMP) pathway

Treatment	Dose (mg/kg)	Number of writhing	Inhibition (%)
Control	0.1 mL/ mouse	71.74 ± 1.77	–
Methylene Blue (MB)	20	58.20 ± 2.89***	18.87
MEDS + MB	100 + 20	37.90 ± 0.96**	47.17
MEDS + MB	200 + 20	26.10 ± 1.69***	63.62
MEDS + MB	400 + 20	15.90 ± 1.52***	77.84

Values are presented as mean ± SEM (n = 5). MEDS Methanolic extract of D. sissoo
*** p < 0.001 compared with the control group (Dunnett’s test)
** p < 0.01 compared with the control group (Dunnett’s test)

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