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Table 4 Effect of N.alba AEE on CCl4-induced changes in the liver function parameters in rats. Rats were intoxicated with CCl4 (0.5 ml/kg; I.P.) and treated with N. alba (100 and 200 mg/kg; P.O.) and silymarin (100 mg/kg; P.O.) for 5 days. ALT, AST, total bilirubin, GGT and ALP were measured

From: Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity

Parameter Control CCl4 N.alba extract Silymarin (100 mg/kg)
Low Dose (100 mg/kg) High Dose (200 mg/kg)
ALT (U/L)1 32.6 ± 3.1 88.1 ± 7.3a 58.4 ± 4b 41.9 ± 2.6b 38.1 ± 2.2b
AST (U/L)2 68.5 ± 3.5 139 ± 8.3a 105.9 ± 4.1b 82.1 ± 6.1b 72.5 ± 4.7b
Total Bilirubin (mg/dl) 0.2 ± 0.02 1.2 ± 0.1a 0.5 ± 0.03b 0.3 ± 0.03b 0.2 ± 0.02b
GGT (U/L)3 7.7 ± 0.6 35.9 ± 3.3a 20.8 ± 1.8b 12.9 ± 1.2b 12 ± 1.2b
ALP (U/L)4 278.5 ± 19.1 496.5 ± 38.3a 414.7 ± 10.9b 346.6 ± 22.8b 294.2 ± 15.4b
  1. Data are presented as the mean ± SEM, n = 8. aSignificant difference from control group; P < 0.05. bSignificant difference from CCl4 group; P < 0.05
  2. 1Alanine aminotransferase
  3. 2Aspartate aminotransferase
  4. 3Gamma glutamyl transpeptidase
  5. 4Alkaline phosphatase