Fig. 2

Buja attenuates the activation of spinal astrocytes in oxaliplatin-injected rats. A Representative images of GFAP positive cells in the spinal dorsal horn of group1: Vehicle + DW (a), group2: Vehicle + Buja (b), group3: Oxaliplatin + DW (c) and group4: Oxaliplatin + Buja (d). Note the increased number of GFAP positive cells and the altered morphology (somatic hypertrophy with thick processes) in the group3 (c), indicating activation of astrocytes. B Quantification result of GFAP positive cells. Six lumbar spinal cord section images from single animal were averaged. N = 6 rats/group. Data are presented as mean ± SEM. *** p < 0.001, vs. group1; ^### p < 0.001, vs. group3, by one-way ANOVA followed by Bonferroni’s post-test