Fig. 1

Inhibitory effect of Buja on cold and mechanical allodynia in oxaliplatin-injected rats. a Time course of tail withdrawal latency (TWL) in response to cold water (4 °C) stimuli. An oxaliplatin injection (group3: Oxaliplatin + DW) induced a significant decrease in TWL since day 3 (D + 3) compared to a vehicle injection (group1: Vehicle + DW). Daily oral administration of Buja (300 mg/kg) for 5 days following an oxaliplatin injection (group4: Oxaliplatin + Buja) significantly inhibited cold allodynia, whereas Buja had no effect on TWL in vehicle-injected rats (group2: Vehicle + Buja). b Time course of mechanical threshold. An oxaliplatin injection (group3) significantly decreased 50% threshold since day 3 compared to a vehicle injection (group1). Buja administration following an oxaliplatin injection (group4) significantly inhibited mechanical allodynia, whereas Buja had no effect on mechanical threshold in vehicle-injected rats (group2). N = 6 rats/group. Data are presented as mean ± SEM. * p < 0.05, *** p < 0.001, vs. group1; ^### p < 0.001, vs. group3, by two-way ANOVA followed by Bonferroni’s post-test