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Table 3 Effects of various treatments on body weight variation and relative organ weights of immature castrated rats after four weeks of treatment

From: Androgenic effects of aqueous and methanolic extracts of Ficus asperifolia in male Wistar rats

Treatments Body weight (g) Body weight variation (%) Relative organ weights (mg/100 g)
Initial Final Epididymis Vas deferens Ventral prostate Seminal vesicles
Normal plus distilled water (10 ml/kg b.w.) 120.00 ± 6.4 173.40 ± 8.84 44.63 ± 1.94 232.78 ± 21.60 63.32 ± 5.05 41.37 ± 7.23 186.47 ± 30.51
Castrated plus distilled water (10 ml/kg b.w.) 124.8 ± 7.53 179 ± 14.89 43.17 ± 7.56 42.47 ± 5.94C 16.06 ± 2.15C 5.69 ± 0.54C 10.00 ± 1.81C
Castrated plus testosterone (0.5 mg/kg b.w.) 125.6 ± 3.41 207 ± 5.5 65.08 ± 4.69*** 143.10 ± 2.67*** 50.45 ± 3.52*** 86.34 ± 2.93*** 244.53 ± 23.11***
5% Tween 80 (10 ml/kg b.w.) + testosterone 120 ± 5.91 179.8 ± 15.16 49.15 ± 6.05** 141.15 ± 13.29*** 51.36 ± 3.90*** 68.83 ± 14.66*** 243.75 ± 58.42***
Bicalutamide (2 mg/kg b.w.) + testosterone 127.4 ± 5.63 196.8 ± 15.39 54.30 ± 7.98 83.93 ± 7.98 38.30 ± 3.79## 26.76 ± 0.82### 112.54 ± 18.45###
F. asperifolia
 Aqueous extract
  100 mg/kg b.w. 120 ± 6.44 167 ± 5.89 39.73 ± 2.82 77.20 ± 5.00* 18.89 ± 0.91 10.35 ± 1.90 19.11 ± 2.24
  500 mg/kg b.w. 121 ± 8.28 161.8 ± 9.29 34.12 ± 1.90 61.76 ± 10.99 25.09 ± 3.72 11.06 ± 1.75 19.60 ± 3.77
 Methanolic extract
  100 mg/kg b.w. 121.6 ± 5.9 174.6 ± 7.69 43.76 ± 2.20 38.62 ± 1.04 12.67 ± 0.39 6.74 ± 0.72 17.18 ± 1.87
  500 mg/kg b.w. 120.8 ± 1.61 169.8 ± 9.04 40.50 ± 0.75 40.18 ± 6.76 15.89 ± 2.18 8.074 ± 1.50 21.28 ± 4.49
 Testosterone (0.5 mg/kg b.w.) plus aqueous extract
  100 mg/kg b.w. 125.8 ± 5.06 184.6 ± 9.55 46.50 ± 2.93### 162.37 ± 8.60 54.85 ± 1.91 100.00 ± 8.43 322.15 ± 30.10#
  500 mg/kg b.w. 126.2 ± 3.93 187.4 ± 5.03 48.62 ± 1.91### 165.86 ± 9.65 61.51 ± 4.03# 101.38 ± 2.66 325.08 ± 16.12#
 Testosterone plus methanolic extract
  100 mg/kg b.w. 120.4 ± 5.91 175.6 ± 8.32 45.96 ± 2.39### 182.87 ± 16.88## 72.86 ± 5.29### 162.15 ± 17.84### 544.91 ± 62.23###
  500 mg/kg b.w. 122 ± 4.51 185 ± 4.16 52.12 ± 3.95 137.50 ± 8.16 65.16 ± 3.99## 146.33 ± 11.15### 455.53 ± 36.05###
 Bicalutamide (2 mg/kg b.w.) plus aqueous extract
  100 mg/kg b.w. 125.8 ± 5.79 183.8 ± 5.49 47.64 ± 5.67 79.35 ± 7.16 23.83 ± 2.64 6.315 ± 1.23 31.90 ± 4.28
  500 mg/kg b.w. 122.2 ± 5.3 183.4 ± 9.36 50.07 ± 1.99 34.74 ± 7.39 10.29 ± 2.64 1.31 ± 0.36 13.21 ± 1.85
 Bicalutamide plus methanolic extract
  100 mg/kg b.w. 120.8 ± 4.89 161.6 ± 6.27 34.12 ± 4.71 33.34 ± 3.46 15.57 ± 1.90 4.79 ± 0.47 15.68 ± 2.34
  500 mg/kg b.w. 120 ± 5.97 167 ± 7.83 39.40 ± 3.63 43.35 ± 3.41 19.01 ± 0.67 7.63 ± 0.75 17.45 ± 1.93
  1. All values: Mean ± SEM; Number of rats per group =5; C: p < 0.001 compared to normal rats; *: p < 0.05; ***: p < 0.001 compared to castrated distilled water treated rats; #: p < 0.05; ##: p < 0.01; ###: p < 0.001 compared to testosterone group; : p < 0.05; : p < 0.01; : p < 0.001 compared to rats treated only with plant extracts