In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice

Table 3 Effect of crude extracts of S. mitis leaves on body weight of P. berghei infected mice

Test substance	Dose (mg/kg)	Body weight		% change
Test substance	Dose (mg/kg)	D₀ (g)	D₄ (g)	% change
AE	200	30.33 ± 1.93	28.28 ± 3.82	−8.29 ± 9.97 c¹,e²,d²
	400	29.83 ± 1.40	30.35 ± 1.35	1.65 ± 3.53 a¹,b¹
	600	29.40 ± 1.69	30.76 ± 1.73	4.41 ± 2.72 a²,b²
Vehicle	1 ml	29.26 ± 1.26	27.30 ± 1.10	−7.18 ± 1.52
CQ	25	29.11 ± 1.54	30.12 ± 2.03	3.21 ± 3.50
HE	200	31.33 ± 0.54	29.88 ± 2.58	−5.43 ± 8.30
	400	29.63 ± 1.45	30.16 ± 1.32	1.73 ± 3.442 a¹
	600	30.41 ± 1.92	32.45 ± 2.23	6.22 ± 1.02 a³,b²
Vehicle	1 ml	29.26 ± 1.26	27.30 ± 1.10	−7.18 ± 1.52
CQ	25	29.11 ± 1.54	30.12 ± 2.03	3.21 ± 3.50

Data are expressed as mean ± SEM; n = 6; a = compared to distilled water (vehicle); b = compared to200 mg/kg; c = compared to 400 mg/kg; d = compared to600 mg/kg; e = compared to CQ 25 mg/kg
D ₀ pre-treatment value on day 0, D ₄ post-treatment value on day four, AE aqueous extract, CQ chloroquine, HE hydro-methanolic extract
¹ = p < 0.05, ² = p < 0.01, ³ = p < 0.001

ISSN: 2662-7671