In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice

Table 2 Effect of crude extract of the leaves of S. mitis on parasitaemia, percent suppression and survival time of P. berghei infected mice

Test substances	Dose (mg/kg)	% parasitaemia	%suppression	Survival time (day)
AE	200	31.65 ± 7.69	29.43 a³,c³,d³,e³	9.83 ± 1.32 a²,c²,d³,e³
	400	11.27 ± 4.05	74.86 a³,b³,d²,e³	12.33 ± 1.63 a³,b²,d³,e³
	600	2.01 ± 0.55	95.50 a³,b³,c²	17.50 ± 1.04 a³,b²,c³,e³
Vehicle	1 ml	44.85 ± 5.81	0.00	7.33 ± 0.81
CQ	25	0.00	100	27.50 ± 0.83
HE	200	28.45 ± 5.27	36.56a³,c³,d³,e³	10.83 ± 1.72a²,d³,e³
	400	8.30 ± 5.03	81.49a³,b³,e²	13.00 ± 2.00a³,e³,d²
	600	2.70 ± 1.10	93.97a³,b³	16.50 ± 1.04a³,b³,c²,e³
Vehicle	1 ml	44.85 ± 5.81	0.00	7.33 ± 0.81
CQ	25	0.00	100	27.50 ± 0.83

Data are expressed as mean ± SEM; n = 6; a = compared to distilled water (vehicle); b = compared to200 mg/kg; c = compared to 400 mg/kg; d = compared to 600 mg/kg; e = compared to chloroquine (25 mg/kg)
AE aqueous extract, CQ chloroquine, HE hydro-methanolic extract
¹ = p < 0.05, ² = p < 0.01, ³ = p < 0.001

ISSN: 2662-7671