From: Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes
Substrates | Concentration Number | ||||||
---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | |
Caffeine(CAF) | 1.875 | 3.75 | 7.5 | 15 | 30 | 60 | 120 |
Tolbutamide(D860) | 0.625 | 1.25 | 2.5 | 5 | 10 | 20 | 40 |
(S)- Mephenytoin(MT) | 1.25 | 2.5 | 5 | 10 | 20 | 40 | 60 |
Dextromethorphan(DM) | 2.5 | 5 | 10 | 20 | 40 | 80 | 160 |
Chlorzoxazone(CLZ) | 1.25 | 2.5 | 5 | 10 | 20 | 40 | 60 |
Midazolam(MDZ) | 0.313 | 0.625 | 1.25 | 2.5 | 5 | 10 | 20 |