Fig. 2From: Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomesGeneral and pathological study in vivo. a Survival proportions during oral administration of TP of different dosage. b Effects of TP of different dosage on body weight in rats: Rats were orally treated with vehicle or 200, 400 or 600 μg/kg/day of TP for 28 days. Symbols and bars represent the mean ± SD, respectively; *P < 0.05, **P < 0.01 versus the control group. c Effects of TP of different dosage on liver index in rats showed no significant difference. d-g Pathological study of liver from the control group (d), 200 μg/kg/day (e), 400 μg/kg/day(f), or 600 μg/kg/day (g) for 28 days. d showed no remarkable changes; (e-f) showed apparent degeneration of liver cell, infiltration of inflammatory cells in hepatic lobules and portal areaBack to article page