The plant was used in folk medicine for the treatment of psoriasis in South Africa , Turkey , Pakistan , India , Middle East , Palestine [17, 39] and Mexico .
Hydrophilic cream and gel of Aloe vera were tried and showed significant improvement against psoriasis in a randomized clinical trial [24, 25]. In another study, topical Aloe vera with 0.1% triamcinolone acetonide was used in mild to moderate plaque psoriasis. Aloe showed its ability to reduce the clinical symptoms of psoriasis .
Aloe extract showed anti-psoriatic activity of 81.95%, compared with 87.94 for tazarotene in the mouse tail model of psoriasis .
Localized side effects including dryness, stinging, soreness, fissures, erythema and contact urticaria may develop after using topical Aloe [25, 43, 44].