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Table 5 Summary of published ethnopharmacological uses, side effects, in vivo and in vitro activity of the most frequently used plants against psoriasis

From: Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine

Plant species Reported ethnopharmacological use with reference source In vivo and in vitro activity against psoriasis with reference source Side effects and toxicity with reference source
Aloe vera The plant was used in folk medicine for the treatment of psoriasis in South Africa [34], Turkey [35], Pakistan [36], India [37], Middle East [38], Palestine [17, 39] and Mexico [40]. Hydrophilic cream and gel of Aloe vera were tried and showed significant improvement against psoriasis in a randomized clinical trial [24, 25]. In another study, topical Aloe vera with 0.1% triamcinolone acetonide was used in mild to moderate plaque psoriasis. Aloe showed its ability to reduce the clinical symptoms of psoriasis [41]. Aloe extract showed anti-psoriatic activity of 81.95%, compared with 87.94 for tazarotene in the mouse tail model of psoriasis [42]. Localized side effects including dryness, stinging, soreness, fissures, erythema and contact urticaria may develop after using topical Aloe [25, 43, 44].
Trigonella arabica The plant was used in ethnomedicine for treatment of psoriasis in Palestine [45] and Pakistan [46]. No reference No reference
Catharanthus roseus No reference C. roseus reduced the expression of psoriatic marker, keratin 17 (K17) in human keratinocytes [47]. No reference
Anthemis cotula No reference No reference Contact sensitization [48].