Fig. 1

Anti-arthritic activity of CIE on arthritis score (a) and paw edema (b) in adjuvant-induced arthritis (AIA) mice. The spleen were promptly removed and weighed when the animals sacrificed after CIE was administered i.g. for 28 days. The spleen index (c) were expressed as the ratio (mg/g) of spleen wet weight versus body weight. The data was presented as mean ± S.D. of ten mice per group. ^** p < 0.01, and ^*** p < 0.001 compared with the vehicle control group; ^# p < 0.05, and ^## p < 0.01 compared with the AIA model group