Fig. 4
Ex vivo effects of WIB-801CE on serotonin release. a Ex vivo effects of WIB-801CE on collagen-induced serotonin release. b Ex vivo effects of WIB-801CE on ADP-induced serotonin release. Measurements were carried out as described in “Methods” section. The data are expressed as the mean ± standard deviation (n = 4). *p < 0.05 versus the each agonist-stimulated platelets, #p < 0.05 versus the ADP-stimulated platelets in the presence of WIB-801CE 200 mg/kg-BW. 1) Δ (%) = [(agonist + WIB-801CE 200 mg/kg-BW) – agonist]/agonist × 100