Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds

Table 2 The effect of H. odorata extracts on faces count in castor oil-induced diarrhea in mice

Treatment/Dose	Total number of feces	% Inhibition of defecation	Total number of diarrheal feces	% Inhibition of diarrhea
Saline	13.4 ± 0.24		5.8 ± 0.2
Loperamide	5.4 ± 0.40^a	59.70 ± 2.99	2.2 ± 0.37^a	62.07 ± 6.45
MEHO200	8.6 ± 0.24^a	35.82 ± 1.83	3.6 ± 0.24^a	37.93 ± 4.22
MEHO400	5.8 ± 0.73^b	56.72 ± 5.48	2.6 ± 0.24^b	55.17 ± 4.22
EEHO200	8.4 ± 0.24^a	37.31 ± 1.83	3.4 ± 0.24^c	41.38 ± 4.22
EEHO400	5.6 ± 0.92^b	58.21 ± 6.92	2.4 ± 0.40^c	58.62 ± 6.90
AEHO200	9.2 ± 0.37^c	31.34 ± 2.79	4.2 ± 0.20^c	27.59 ± 3.45
AEHO400	7.0 ± 0.31^d	47.76 ± 2.36	3.2 ± 0.20^d	44.83 ± 3.45

Values are presented as mean ± SEM for 5-6 rats. Data for the total number of feces and total number of diarrheal feces by H. odorata extracts, positive antidiarrheal control (Loperamide, 5 mg/kg p.o.) and normal control (saline) were processed by paired t-test analysis using Statistical package for social Science (SPSS for windows, version 21.0, IBM Corporation, New York, USA) followed by Dunnet test. ^{a, b, c} & ^d superscript letters in the table are statistically significant to each other. Values with P < 0.05 are considered as statistically significant

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