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Table 11 Effect of FOM on GSH, TBARS and DNA fragmentation in acetaminophen induced hepatotoxicity in rats

From: Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat

Treatment mg/kg bw

GSH (μM/g tissue)

TBARS (nM/min/mg protein)

DNA fragmentation %

Total protein (μg/mg tissue)

Control (Saline)

25.52 ± 0.63d

1.85 ± 0.01d

6.12 ± 0.01d

4.90 ± 0.17d

AMP 750

10.96 ± 0.25a

5.17 ± 0.18a

32.18 ± 1.23a

2.58 ± 0.52a

AMP + Sily 50

25.01 ± 0.64d

1.71 ± 0.04d

7.11 ± 0.16d

3.96 ± 0.63b

AMP + FOM 200

17.23 ± 0.15b

3.63 ± 0.53b

22.85 ± 1.05b

2.87 ± 0.52a

AMP + FOM 400

22.76 ± 0.14c

2.51 ± 0.16c

15.42 ± 1.32c

3.64 ± 0.13c

FOM 400

25.14 ± 0.31d

1.21 ± 0.50e

8.31 ± 0.03d

4.45 ± 0.22d

  1. Mean ± SEM (06). Means with different superscript letters (a-e) within the column indicate significant difference (p <0.05). AMP, acetaminophen; FOM, F. olivieri methanol extract