Skip to main content

Advertisement

Table 11 Effect of FOM on GSH, TBARS and DNA fragmentation in acetaminophen induced hepatotoxicity in rats

From: Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat

Treatment mg/kg bw GSH (μM/g tissue) TBARS (nM/min/mg protein) DNA fragmentation % Total protein (μg/mg tissue)
Control (Saline) 25.52 ± 0.63d 1.85 ± 0.01d 6.12 ± 0.01d 4.90 ± 0.17d
AMP 750 10.96 ± 0.25a 5.17 ± 0.18a 32.18 ± 1.23a 2.58 ± 0.52a
AMP + Sily 50 25.01 ± 0.64d 1.71 ± 0.04d 7.11 ± 0.16d 3.96 ± 0.63b
AMP + FOM 200 17.23 ± 0.15b 3.63 ± 0.53b 22.85 ± 1.05b 2.87 ± 0.52a
AMP + FOM 400 22.76 ± 0.14c 2.51 ± 0.16c 15.42 ± 1.32c 3.64 ± 0.13c
FOM 400 25.14 ± 0.31d 1.21 ± 0.50e 8.31 ± 0.03d 4.45 ± 0.22d
  1. Mean ± SEM (06). Means with different superscript letters (a-e) within the column indicate significant difference (p <0.05). AMP, acetaminophen; FOM, F. olivieri methanol extract