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Table 3 Effects of the aqueous extract of V. heterophylla on saluretic and natriuretic activity from 24 h of urine

From: Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Drugs (mg/kg)

Saluretic (Na+ + Cl)

Natriuretic (Na+/k+)

CAI Cl/(Na + K)

Saluretic index

Natriuretic index

CAI index

Control

42.65 ± 2.52

1.00 ± 1.68

0.45 ± 0.55

1.00

1.00

1.00

Extract

150

112.38 ± 3.55***

1. 34 ± 1.70*

0.47 ± 0.37*

2.63

1.34

1.04

200

219.66 ± 2.74***

1.86 ± 1.09**

0.48 ± 0.51**

5.15

1.86

1.06

250

324.95 ± 2.64***

3.17 ± 0.57***

0.48 ± 0.53**

7.61

3.17

1.06

Furosémide (5 mg/kg)

201.43 ± 4.33***

2.49 ± 0.95***

0.49 ± 0.51**

4.72

2.49

1.08

Amiloride H. (10 mg/kg)

158.99 ± 3.42***

2.75 ± 1.15***

0.48 ± 0.61**

3.72

2.75

1.06

  1. Values are means ± S.E.M., n = 5, * < 0.05, ** < 0.01, *** < 0.001, significant difference compared to the control
  2. CAI, carbonic anhydrase inhibition
  3. saluretic index: saluretic activity in test group/saluretic activity in control group
  4. natriuretic index: natriuretic activity in test group/natriuretic activity in control group
  5. carbonic anhydrase inhibition index, CAI activity in test group/CAI activity in control group