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Table 3 Metabolic parameters in treatment groups before and after intervention

From: The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial

N Nigella sativa Placebo P
N = 20 N = 20
TSH (mIU/l)
 Before 6.42 ± 3.86 8.14 ± 7.28 0.35
 After 4.13 ± 2.35 8.27 ± 7.21 0.02
P 0.03 0.40  
T3 (mmol/l)
 Before 0.92 ± 0.27 1.18 ± 0.36 0.017
 After 1.06 ± 0.34 1.16 ± 0.35 0.39
P 0.008 0.15  
T4 (mmol/l)
 Before 8.07 ± 2.56 7.97 ± 3.11 0.91
 After 8.89 ± 1.43 7.63 ± 2.23 0.04
P 0.21 0.32  
Anti-TPO (IU/ml)
 Before 294.55 ± 210.05 278.10 ± 170.77 0.78
 After 147.99 ± 158.33 274.30 ± 167.20 0.01
P 0.019 0.28  
Nesfatin-1 (ng/ml)
 Before 41.80 ± 28.33 25.86 ± 20.91 0.049
 After 37.63 ± 5.91 26.75 ± 23.95  
P 0.34 0.69  
VEGF (ng/L)
 Before 3521.13 ± 395.95 2101.73 ± 339.29 0.17
 After 2100.17 ± 36,082 2100.17 ± 360.82 0.25
P 0.02 0.99  
  1. Data are presented as mean ± SD. † P values for ANOCOVA after adjustment for age, gender and baseline concentration of parameter; ‡P values for paired t-test. TSH, thyroid-stimulating hormone; T3 triiodothyronine, T4 thyroxine, VEGF vascular endothelial growth factor, the bolded P values are statistically significant