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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Anvillea garcinii extract inhibits the oxidative burst of primary human neutrophils

Fig. 4

Mechanism of action of A. garcininii (Anv). Polysaccharides extract from Anv strongly inhibits neutrophils response induced by phorbol myristate acetate (PMA) an activator of Protein Kinase C (PKC). Activation of PKC leads to specific phosporylation of p47phox and its translocation to plasma membrane to activate NADPH oxidase (NOX2) which produces ROS. Anv prevents this activation by inhibiting PKC and thus preventing p47phox phosphorylation and its translocation. Further, Anv by its inhibitory action on PKC, is also able to counteract the degranulation of azurophilic and specific granules of activated neutrophils

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