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Table 1 EOs biological potential and selectivity indexes (SI) for L. amazonensis (IC50/24 h) promastigotes and L6 cells (CC50/24 h)

From: Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition

Essential oils L. amazonensis L6 cells SIg
IC50a ± DP (μg/mL) CC50 f ± DP (μg/mL)
Litsea cubeba NIe 180.72 ± 1.37 -
Matricaria chamomilla 60.16 ± 4.24 173.04 ± 1.24 2.87
Elettaria cardamomum >500.00b 439.57 ± 2.27
Lavandula officinalis >500.00 377.56 ± 8.91
Cinnamomum camphora >500.00 >500.00
Myroxylon peruiferum 162.25 ± 1.57 160.80 ± 1.62 0.99
Salvia sclarea 325.92 ± 8.58 375.37 ± 3.62 1.15
Bulnesia sarmientoi 85.56 ± 3.38 163.46 ± 1.77 1.91
Ferula galbaniflua 95.70 ± 1.82 377.26 ± 2.71 3.94
Pelargonium graveolens 363.71 ± 6.77 368.39 ± 3.90 1.01
Cananga odorata NI 142.80 ± 1.76
Foeniculum officinalis 328. 28 ± 6.80 368.27 ± 3.81 1.12
Cordia verbenaceae 64.75 ± 2.04 130.00 ± 1.08 2.01
Melissa officinalis 132.02 ± 3.14 297.45 ± 1.32 2.25
Siparuna guianensis 48.55 ± 3.64 78.02 ± 1.19 1.60
Cinnamodendron dinisii 54.05 ± 4.88 106.31 ± 2.23 1.97
Anfotericina Bc (0.083 ± 0.003 μg/mL) NI
DMSOd NI NI
  1. a) IC50 ± DP: the concentration able to cripple 50 % of the parasites ± standard deviation
  2. b) > 500.00: IC50 greater than the highest concentration tested
  3. c) Amphotericin B - positive control
  4. d) DMSO - negative control
  5. e) NI: no inhibition
  6. f) CC50: the concentration able to cripple 50 % of cells after 24 h of treatment ± standard deviation
  7. g) Selectivity index - SI = CC50 L6 / IC50 promastigotes