Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl4 induced hepatic toxicity in rat

Table 3 Effect of FXM on biochemical parameters of liver in rat

Treatment	Protein (μg/mg tissue)	GSH (μmole/g tissue)	TBARS (nmole/min/mg tissue)	H₂O₂ (nmole/min/mg tissue)	DNA injury (%)
Control	2.98 ± 0.13^a	21.05 ± 2.18^abc	2.96 ± 0.28^d	2.49 ± 0.09^c	2.51 ± 0.15^d
DMSO + Olive oil	2.98 ± 0.09^a	21.35 ± 2.16^ab	3.24 ± 0.36^d	2.60 ± 0.19^bc	2.58 ± 0.15^d
CCl₄	1.05 ± 0.14^†c	11.38 ± 0.93^†e	6.19 ± 0.65^†a	3.99 ± 0.33^†a	6.22 ± 0.63^†a
CCl₄ + silymarin (100 mg/kg)	2.81 ± 0.10^a	17.87 ± 1.01^≠bcd	4.20 ± 0.27^†bc	2.93 ± 0.20^*bc	2.94 ± 0.21^cd
CCl₄ + FXM (200 mg/kg)	1.87 ± 0.13^†b	14.62 ± 1.56d^†e	4.65 ± 0.47^†b	3.04 ± 0.25^≠b	4.50 ± 0.34^†b
CCl₄ + FXM (400 mg/kg)	2.91 ± 0.11^a	17.73 ± 1.00^≠cd	3.80 ± 0.34^≠cd	2.74 ± 0.35^bc	3.38 ± 0.23^†c
FXM (200 mg/kg)	2.90 ± 0.13^a	21.74 ± 1.82^a	2.95 ± 0.19^d	2.51 ± 0.21^c	2.55 ± 0.09^d
FXM (400 mg/kg)	2.89 ± 0.11^a	22.35 ± 1.65^a	3.13 ± 0.33^d	2.49 ± 0.18^c	2.49 ± 0.16^d

FXM F. xanthoxyloides methanol extract. Data values shown represent mean ± SD (n = 6). One way analysis of variance was followed by Dunnet comparison of various treatments with control at: ^*, P < 0.05; ^#, P < 0.01; ^ǂ, P < 0.001. Multiple comparisons among treatments were determined by Tukeys’ HSD test. Superscript alphabets indicate significance among treatments (P < 0.01) on not sharing common letter

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