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Table 1 Effect of FXM on biochemical parameters of serum in rat

From: Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl4 induced hepatic toxicity in rat

Treatment

AST (U/l)

ALT (U/l)

Bilirubin (mg/dl)

Albumin (mg/dl)

Globulin (mg/dl)

Control

86.66 ± 5.35d

32.66 ± 4.17 d

0.165 ± 0.024c

4.45 ± 0.27a

1.55 ± 0.18c

DMSO + Olive oil

89.50 ± 6.05 d

33.16 ± 3.65 d

0.160 ± 0.025c

4.60 ± 0.17a

1.52 ± 0.18bc

CCl4

319.83 ± 20.22†a

204.67 ± 20.91†a

0.663 ± 0.132†a

2.33 ± 0.31†b

2.27 ± 0.10†a

CCl4 + silymarin (100 mg/kg)

122.00 ± 21.07≠c

63.50 ± 5.28†c

0.256 ± 0.043*bc

3.93 ± 0.21a

1.81 ± 0.26bc

CCl4 + FXM (200 mg/kg)

212.67 ± 29.04†b

105.50 ± 6.53†b

0.325 ± 0.030†b

4.00 ± 0.50a

2.13 ± 0.09†ab

CCl4 + FXM (400 mg/kg)

116.83 ± 12.25*cd

61.33 ± 6.21†c

0.161 ± 0.030c

4.23 ± 0.47a

2.09 ± 0.23†ab

FXM (200 mg/kg)

84.83 ± 5.07 d

36.66 ± 3.66 d

0.156 ± 0.021c

4.35 ± 0.18a

1.51 ± 0.14c

FXM (400 mg/kg)

86.66 ± 4.88 d

33.16 ± 3.06 d

0.161 ± 0.023c

4.43 ± 0.32a

1.60 ± 0.14c

  1. FXM F. xanthoxyloides methanol extract. Data values shown represent mean ± SD (n = 6). One way analysis of variance was followed by Dunnet comparison of various treatments with control at: *, P < 0.05; #, P < 0.01; ǂ, P < 0.001. Multiple comparisons among treatments were determined by Tukeys’ HSD test. Superscript alphabets indicate significance among treatments (P < 0.01) on not sharing common letter