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Table 4 The percentage of maximum possible effect (%MPE) of MECC in tail immersion test

From: Antinociceptive effect of methanol extract of Celosia cristata Linn. in mice

Treatment

Dose (mg/kg)

%MPE

30 min

45 min

60 min

90 min

120 min

Vehicle

-

1.95 ± 1.15

0.87 ± 0.83

0.10 ± 1.44

0.32 ± 1.07

0.71 ± 1.20

NLX

2 (i.p.)

1.12 ± 1.18

1.74 ± 1.99

1.25 ± 1.33

2.43 ± 1.42

2.09 ± 0.74

MECC

50

4.35 ± 0.57

6.55 ± 0.97

8.99 ± 1.60

10.77 ± 1.38*

5.40 ± 1.56

MECC

100

5.04 ± 1.18

8.57 ± 2.17

10.28 ± 2.11

10.05 ± 2.31*

9.88 ± 1.88

MECC

200

6.15 ± 1.56

11.36 ± 1.65

14.65 ± 1.71*

16.12 ± 0.58*

14.39 ± 1.32*

MECC

400

9.97 ± 1.02*

14.46 ± 0.95*

19.51 ± 0.56*

22.60 ± 1.33*

17.91 ± 1.79*

Morphine

5 (i.p.)

36.98 ± 1.39*

50.92 ± 4.19*

56.30 ± 2.72*

35.65 ± 2.07*

29.17 ± 3.41*

  1. Each value is presented as the mean ± SEM (n = 5). MECC = Methanol extract of C. cristata; NLX = Naloxone. * represents p < 0.001, compared with the control group (Dunnett’s test)