Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

Table 2 Effect of carob pods extract (CPE) administration on worm burden, liver tissue eggs load and granuloma size of S. mansoni infected mice

Groups	Mean number of worms ± SEM	Reduction on worm burden (%)	Ova count in liver ± SEM	Reduction on ova count (%)	Granuloma size (μm²)
Vehicle control	15.3 ± 1.37	-	11.4 ± 1.08	-	968500 ± 1364
PZQ (500 mg/kg bwt)	4.7 ± 0.52^a	69.5^a	2.3 ± 0.71^a	79.8^a	915400 ± 1519
CPE (300 mg/kg bwt)	9.3 ± 1.36^a	39.0^a	5.7 ± 0.34^a	50.0^a	882200 ± 757^a
CPE (600 mg/kg bwt)	7.0 ± 0.89^a	54.2^a	3.1 ± 0.28^a	72.8^a	808900 ± 361^a

Values are means ± SEM (n = 5). ^a p < 0.05, significant change with respect to the Vehicle control

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