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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity

Fig. 7

Effects of DFE and DPE on fibrolytic markers in CCl4-intoxicated rats. (a): Light microscopic photomicrographs of liver tissue immunostained with anti TIMP-2 primary antibody (Scale bar = 100 μm). Panel a represents liver section from control rat showing normal absence of immune positivity. Panel b represents liver section of rat intoxicated with CCl4 in which there are focal strong wide areas of abnormal immune reactivity of most of hepatic tissue. Panels c d and e represents liver sections from rats treated with DFE, DPE and coffee, respectively, revealed a decrease of immunostained areas which appeared weak in reaction. (b): Effect of DFE, DPE and coffee on hepatic levels of TIMP-1 in CCl4-intoxicated rats. Values are expressed as mean ± SEM. a: significantly different from normal control group; b: significantly different from CCl4-treated group; c: significantly different from DFE-treated rats. *** P < 0.001, * P < 0.05

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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