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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity

Fig. 4

Effect of DFE, DPE and coffee on collagen deposition in CCl4-intoxicated rats. (a): Light microscopic photomicrographs of liver tissue immunostained with anti-collagen type I primary antibody (Scale bar = 100 μm). Panel a represents liver section from control group showing normal faint immunopositive areas that restricted to the portal areas (arrow). Panel b represents liver section of rat received CCl4 showing dense abnormal immune positivity of scattered patches near to the degenerated areas (arrows). Liver sections from rats treated with DFE (Panel c), DPE (Panel d) and coffee (Panel e) showing marked decrease of amount and density of abnormal fibrosis (arrows). The improvement is prominent in DFE-treated group. (b): Light microscopic photomicrographs of liver tissue immunostained with anti-collagen III primary antibody (Scale bar = 50 μm). Panel a represents liver section from control group showing normal immunopositive collagen distribution mainly in portal area (arrow), while Panel b represents liver section of rat received CCl4 in which strong wide abnormal irregularly distributed immune reactivity (arrow) was detected. Panels c d and e represent liver sections from rats treated with DFE DPE and coffee, respectively showing marked decrease of the intensity of the immune reactivity of hepatocytes surrounding portal areas especially in rats received DFE (arrows)

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