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Table 2 Defensive effect of PELE on tissue proteins, GSH, TBARS, nitrite and H2O2 contents in lungs of rat

From: Evaluation of phytochemicals, antioxidant activity and amelioration of pulmonary fibrosis with Phyllanthus emblica leaves

Treatment

Protein (μg/mg tissue)

GSH (nmole/min/mg protein)

TBARS (nmole/mg protein)

Nitrite (μM/mL)

H2O2 (nmole/mg tissue)

Control

2.5 ± 0.4a

22.0 ± 1.5a

3.1 ± 0.3f

34.5 ± 2.5f

1.03 ± 0.1f

Vehicle

2.4 ± 0.6a

21.6 ± 2.6a

3.9 ± 0.8e

39.4 ± 2.0e

1.25 ± 0.3e

CCl4 (1 mL/kg)

0.4 ± 0.5d

8.5 ± 2.2d

6.9 ± 1.1a

59.2 ± 2.5a

3.43 ± 0.3a

CCl4 + silymarin

2.2 ± 0.3ab

19.7 ± 2.4b

4.6 ± 0.4b

43.2 ± 1.2c

2.30 ± 0.4b

CCl4 + PELE (200 mg/kg) bw)

1.2 ± 0.16c

15.8 ± 1.2c

4.4 ± 0.9bc

45.0 ± 1.6b

2.17 ± 0.5c

CCl4 + PELE (400 mg/kg) bw)

2.1 ± 0.8b

19.7 ± 1.5b

4.1 ± 0.6de

41.6 ± 2.1d

1.95 ± 0.2d

PELE (400 mg/kg)

2.3 ± 0.7ab

20.9 ± 1.5ab

4.2 ± 0.5cd

42.1 ± 1.0cd

2.06 ± 0.3cd

  1. Mean ± SD (n = 6), a-f (Means with different superscript letters) specify significance at P < 0.01, PELE; methanolic extract of P. emblica leaves