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Table 2 CNS depressant activity of Stericulia villosa extract on thiopental sodium induced sleeping time test in mice

From: In vivo sedative activity of methanolic extract of Stericulia villosa Roxb. leaves

Group

Treatment, Dose & Route (p.o)

Thiopental sodium induced sleeping time test

Elevated plus-maze (EPM) test

Onset of sleep (Min)

Duration of sleep (Min)

% Entry into open arm

Control

1 % tween 80 in water, 10 ml/kg

40 ± 3.701

62 ± 2.121

12.30 ± 2.286*

Standard

Diazepam, 1 mg/kg

11.80 ± 1.9235*

180 ± 7.694*

29.40 ± 3.286*

Test

MESV, 400 mg/kg

9 ± 4.336*

230 ± 5.805*

42 ± 9.970*

  1. All values are expressed as mean ± SEM (n = 5); One way Analysis of Variance (ANOVA). *P < 0.05, significant compared to control