Table 2 IC50 values and sensitization ratio of conventional chemotherapeutic drugs and its combinations with MF towards human colorectal cancer cell lines SW1116 and SW837
Single and combined treatment with chemotherapeutic drugs and MF | SW1116 | ||
IC50 (M)a | Sensitization ratiob | Pc values | |
CPT (128× 10−11- 1× 10−4 M) | 2.0 × 10−5 | - | |
CPT (128× 10−11 - 1× 10−4 M) + MF (1.5 mM) | 21 × 10−8 | 95.0 | 0.025 |
5FU (89.6× 10−10- 0.7× 10−3 M) | 8.83 × 10−6 | - | |
5FU (89.6× 10−10- 0.7× 10−3 M) + MF (1.5 mM) | 84 × 10−10 | 1051 | 0.025 |
DOX (110× 10−12 - 0.86× 10−5 M) | 0.43 × 10−4 | - | |
DOX (110× 10−12 - 0.86× 10−5) + MF (1.5 mM) | 3.44 × 10−7 | 125 | 0.081 |
TAX (94× 10−11- 1.47× 10−4 M) | 1.47 × 10−4 | - | |
TAX (94× 10−11- 1.47× 10−4 M) + MF (1.5 mM) | 5.72 × 10−6 | 26 | 0.183 |
VBL (3.84× 10−11 - 0.03× 10−4 M) | 0.22 × 10−8 | - | |
VBL (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 3.52 × 10−11 | 62.55 | 0.326 |
VCR (3.84× 10−11 - 0.03× 10−4 M) | 0.4 × 10−8 | - | |
VCR (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 3.15 × 10−11 | 254 | 0.079 |
ETP (5.12× 10−10 - 0.04× 10−3M) | 1.19 × 10−6 | - | |
ETP (5.12× 10−10 - 0.04× 10−3M) + MF (1.5 mM) | 5.4 × 10−10 | 2204 | 0.026 |
ELP (2.56× 10−10 - 0.02× 10−3M) | 0.06 × 10−4 | - | |
ELP (2.56× 10−10 - 0.02× 10−3M) + MF (1.5 mM) | 1.3 × 10−9 | 4615 | 0.001 |
AMS (1.28× 10−10- 0.01× 10−3M) | 0.013 × 10−3 | - | |
AMS (1.28× 10−10- 0.01× 10−3M) + MF (1.5 mM) | 0.2 × 10−7 | 650 | 0.001 |
HHG (25.6× 10−12 – 0.2× 10−5M) | 2.0 × 10−7 | - | |
HHG (25.6× 10−12 – 0.2× 10−5M) + MF (1.5 mM) | 3 × 10−9 | 67 | 0.010 |
Single and combined treatment with chemotherapeutic drugs and MF | SW837 | ||
IC50 (M)a | Sensitization ratiob | Pc values | |
CPT (128× 10−11- 1× 10−4 M) | 5 × 10−5 | - | |
CPT (128 × 10−11- 1× 10−4 M) + MF (1.5 mM) | 4 × 10−6 | 12.5 | 0.012 |
5FU (89.6× 10−10- 0.7× 10−3 M) | 0.7 × 10−3 | - | |
5FU (89.6× 10−10- 0.7× 10−3 M) + MF (1.5 mM) | 2.6 × 10−5 | 269 | 0.001 |
DOX (110× 10−12 - 0.86× 10−5 M) | 3.44 × 10−6 | - | |
DOX (110× 10−12 - 0.86× 10−5) + MF (1.5 mM) | 27.5 × 10−8 | 12.5 | 0.005 |
TAX (94× 10−11- 1.47× 10−4 M) | 1.47 × 10−4 | - | |
TAX (94× 10−11- 1.47× 10−4 M) + MF (1.5 mM) | 5.86 × 10−6 | 25 | 0.045 |
VBL (3.84× 10−11 - 0.03× 10−4 M) | 0.11 × 10−6 | - | |
VBL (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 0.44 × 10−8 | 25 | 0.060 |
VCR (3.84× 10−11 - 0.03× 10−4 M) | 0.2 × 10−7 | - | |
VCR (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 2.4 × 10−9 | 8.33 | 0.119 |
ETP (5.12× 10−10 - 0.04× 10−3M | 0.18 × 10−4 | - | |
ETP (5.12× 10−10 - 0.04× 10−3M) + MF (1.5 mM) | 0.51 × 10−6 | 35 | 0.003 |
ELP (2.56× 10−10 - 0.02× 10−3M) | 0.02 × 10−3 | - | |
ELP (2.56× 10−10 - 0.02× 10−3M) + MF (1.5 mM) | 0.32 × 10−7 | 625 | 0.001 |
HHG (25.6× 10−12 – 0.2× 10−5M) | 0.6 × 10−6 | - | |
HHG (25.6× 10−12 – 0.2× 10−5M) + MF (1.5 mM) | 2.25 × 10−8 | 27 | 0.012 |