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Table 5 Urinalysis of rats treated with MHEE for 4 weeks

From: Acute and subacute toxicity of an ethanolic extract of Melandrii Herba in Crl:CD sprague dawley rats and cytotoxicity of the extract in vitro

Group

Volume (mL)

Glucosea

Bilirubina

Ketone bodya

Specific gravity

pH

Urobilino-gena

Male rats

 0 mg/kg/day

27 ± 9.9

0/5

0/5

2/5

1.007 ± 0.0027

7.0 ± 0.00

0/5

 500 mg/kg/day

22 ± 5.7

0/5

0/5

3/5

1.010 ± 0.0035

6.9 ± 0.22

0/5

 1000 mg/kg/day

25 ± 18.0

0/5

0/5

3/5

1.010 ± 0.0035

7.0 ± 0.00

0/5

 2000 mg/kg/day

22 ± 11.4

0/5

0/5

4/5

1.012 ± 0.0045

6.8 ± 0.27

0/5

Female rats

 0 mg/kg/day

12 ± 5.7

0/5

0/5

2/5

1.015 ± 0.0061

6.7 ± 0.45

0/5

 500 mg/kg/day

11 ± 6.8

0/5

0/5

3/5

1.014 ± 0.0042

6.8 ± 0.27

0/5

 1000 mg/kg/day

10 ± 1.8

0/5

0/5

5/5

1.017 ± 0.0027

6.5 ± 0.35

0/5

 2000 mg/kg/day

12 ± 6.7

0/5

0/5

4/5

1.015 ± 0.0035

6.6 ± 0.22

0/5

  1. Values are presented as mean ± SD
  2. aNumber of animals with sign/Total number of animals observed