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Table 2 Relative organ weights (g) in rats treated with MHEE for 4 weeks

From: Acute and subacute toxicity of an ethanolic extract of Melandrii Herba in Crl:CD sprague dawley rats and cytotoxicity of the extract in vitro

Dose (mg/kg/day)

0

500

1000

2000

Male rats

 Brain

0.540 ± 0.0392

0.532 ± 0.0381

0.560 ± 0.0204

0.531 ± 0.0577

 Pituitary gland

0.033 ± 0.0003

0.003 ± 0.0002

0.003 ± 0.0004

0.003 ± 0.0004

 Liver

3.207 ± 0.1068

3.104 ± 0.2479

3.280 ± 0.1780

3.422 ± 0.1196

 Spleen

0.200 ± 0.0284

0.195 ± 0.0282

0.207 ± 0.0231

0.221 ± 0.0100

 Heart

0.311 ± 0.0126

0.331 ± 0.0210

0.334 ± 0.0170

0.325 ± 0.0216

 Thymus

0.150 ± 0.0148

0.155 ± 0.0241

0.143 ± 0.0200

0.179 ± 0.0294

 Salivary glands

0.181 ± 0.0229

0.184 ± 0.0084

0.184 ± 0.0118

0.180 ± 0.0101

 Seminal vesicle

0.321 ± 0.0326

0.349 ± 0.0404

0.351 ± 0.0575

0.303 ± 0.0457

 Prostate

0.104 ± 0.0128

0.109 ± 0.0268

0.129 ± 0.0370

0.099 ± 0.0158

 Kidneys

0.818 ± 0.0747

0.833 ± 0.0457

0.831 ± 0.0711

0.824 ± 0.0326

 Adrenal glands

0.015 ± 0.0190

0.015 ± 0.0013

0.015 ± 0.0009

0.016 ± 0.0014

 Testes

0.815 ± 0.0405

0.832 ± 0.0395

0.889 ± 0.0552

0.848 ± 0.1053

 Epididymides

0.276 ± 0.0228

0.265 ± 0.0139

0.267 ± 0.0154

0.259 ± 0.0368

 Lung

0.410 ± 0.0377

0.413 ± 0.0121

0.412 ± 0.0138

0.406 ± 0.0258

 Thyroid/parathyroid

0.005 ± 0.0006

0.006 ± 0.0010*

0.006 ± 0.0006*

0.007 ± 0.0007**

Female rats

 Brain

0.813 ± 0.0508

0.849 ± 0.0871

0.809 ± 0.0386

0.840 ± 0.0616

 Pituitary gland

0.006 ± 0.0006

0.006 ± 0.0007

0.006 ± 0.0004

0.006 ± 0.0007

 Liver

3.138 ± 0.1330

3.278 ± 0.1348

3.33 ± 0.1695

3.497 ± 0.2084**

 Spleen

0.219 ± 0.0495

0.233 ± 0.0307

0.222 ± 0.0183

0.234 ± 0.0250

 Heart

0.388 ± 0.0533

0.382 ± 0.0153

0.357 ± 0.0074

0.371 ± 0.0156

 Thymus

0.221 ± 0.0252

0.200 ± 0.0232

0.227 ± 0.0148

0.232 ± 0.0648

 Salivary glands

0.181 ± 0.0112

0.197 ± 0.0108

0.188 ± 0.0125

0.201 ± 0.0131

 Kidneys

0.859 ± 0.0590

0.917 ± 0.0565

0.837 ± 0.0945

0.905 ± 0.0303

 Adrenal glands

0.031 ± 0.0025

0.033 ± 0.0032

0.030 ± 0.0036

0.033 ± 0.0043

 Ovaries

0.042 ± 0.0049

0.041 ± 0.0041

0.037 ± 0.0067

0.045 ± 0.0061

 Lung

0.543 ± 0.0140

0.544 ± 0.0306

0.537 ± 0.0332

0.522 ± 0.0406

 Thyroid/parathyroid

0.008 ± 0.0006

0.007 ± 0.0013

0.008 ± 0.0014

0.008 ± 0.0011

 Uterus/cervix

0.291 ± 0.1312

0.279 ± 0.0762

0.255 ± 0.1077

0.264 ± 0.0416

  1. Values are presented as the mean ± SD
  2. *, ** indicate a significant difference at P < 0.05 and P < 0.01, respectively, when compared with the vehicle control group
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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