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Fig. 6 | BMC Complementary and Alternative Medicine

Fig. 6

From: A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells

Fig. 6

FVTF inhibits LCSLCs characteristics through down-regulation of p-Akt. a, The expression levels of phosphorylated AKT were compared between SFCs and parental NCI-H446 cells. b, FVTF decreased phosphorylation levels of Akt in LCSLCs in a concentration-dependent manner. c, LY294002 down-regulated phosphorylation levels of Akt in LCSLCs in a concentration-dependent manner. d, LY294002 significantly decreased the tumor sphere forming rate of LCSLCs. e, LY294002 significantly enhanced the inhibition effects of FVTF on tumor sphere formation capacity of LCSLCs. f, LY294002 significantly enhanced the inhibition effects of FVTF on cell invasion capacity of LCSLCs. g, LY294002 significantly enhanced the down-regulation of self-renewal related transcriptional factors by FVTF in LCSLCs. h, LY294002 significantly enhanced the down-regulation of invasion related transcriptional factors by FVTF in LCSLCs

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