Fig. 11

A representative section of the cardiac muscle (a) that retained the normal branching of myocardial cells characteristic of normal myocardial tissue histology (VCG and 900 mg/kg UNCP) (b) that showed very little in terms of deterioration or inflammation (1500 mg/kg UNCP) (c) with evidence of section of the heart with ongoing tissue necrosis in a section of myocardial tissue of one of the animals that received 300 mg/kg UNCP. The region appeared intensely stained indicating the presence of dead cells (arrowed) (d) showing patchy areas of congestion, oedema, extensive nuclear and tissue degeneration leading to loss of microstructure of myocardial tissues (arrowed). This was observed with animals that received 3 day A/L (75 mg/kg) only (NCG)