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Table 1 Cytotoxicity of oligostilbenoid compounds isolated from Dryobalanops towards cancer cell lines and non-tumorigenic cell lines at 72 h reflected by the IC50 values as determined by MTT assay

From: Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231

 

IC50 (μM)

Compound

Flexuosol A

Nepalensinol E

Laevifonol

Ampelopsin F

Ampelopsin E

Malaysianol A

Malaysianol D

Tamoxifen (Positive control)

Doxorubicin

Cell line

MDA-MB-231

27.5 ± 3.54

>30

>30

>30

14.5 ± 0.71

23 ± 4.24

>30

7 ± 1.41

0.4 ± 0

MCF-7

>30

>30

>30

>30

29.5 ± 0.71

>30

>30

11.5 ± 3.54

0.21 ± 0.27

HT-29

>30

>30

>30

>30

>30

N/A

N/A

N/A

N/A

A-549

>30

>30

>30

>30

>30

N/A

N/A

N/A

N/A

HeLa

>30

>30

>30

>30

>30

N/A

N/A

N/A

N/A

3T3

>30

>30

>30

>30

>30

N/A

N/A

N/A

N/A

MCF10A

>30

N/A

N/A

N/A

>30

>30

>30

N/A

>10

  1. Each data point represents the mean of two independent experiments ± SD