Skip to main content

Table 3 IC50 values, CC50s and Selectivity index (SI) values of the O. ochengi adult female hits on the different O. ochengi parasite stages tested

From: Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum

  

Extract

Nature of parameter

Parameter

TBRhex

PULhex

PULmc

PULmet

PURhex

PURmc

PURmet

PUShex

PUSmc

Inhibition of adult male worm motility

IC50 (μg/mL)

131.7

33.26

16.63

31.25

43.22

48.89

34.89

32.82

43.22

CC50 (μg/mL)

375

93.75

93.75

93.73

46.88

93.75

93.75

46.88

46.88

SI

2.8

2.8

5.6

3.0

1.1

1.9

2.7

1.4

1.1

Inhibition of formazan formation by female worms

IC50 (μg/mL)

213.5

67.87

35.65

125.30

37.36

162.70

125.30

37.79

37.36

CC50 (μg/mL)

375

93.75

93.75

93.73

46.88

93.75

93.75

46.88

46.88

SI

1.8

1.4

2.6

0.75

1.3

0.6

0.7

1.2

1.3

Inhibition of mf motility

IC50 (μg/mL)

154.8

62.50

125.0

31.25

55.61

62.50

31.25

31.25

125.0

CC50 (μg/mL)

375

93.75

93.75

93.73

46.88

93.75

93.75

46.88

46.88

SI

2.4

1.5

2.9

3.0

1.5

1.7

1.5

1.5

1.5