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Table 3 IC50 values, CC50s and Selectivity index (SI) values of the O. ochengi adult female hits on the different O. ochengi parasite stages tested

From: Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum

   Extract
Nature of parameter Parameter TBRhex PULhex PULmc PULmet PURhex PURmc PURmet PUShex PUSmc
Inhibition of adult male worm motility IC50 (μg/mL) 131.7 33.26 16.63 31.25 43.22 48.89 34.89 32.82 43.22
CC50 (μg/mL) 375 93.75 93.75 93.73 46.88 93.75 93.75 46.88 46.88
SI 2.8 2.8 5.6 3.0 1.1 1.9 2.7 1.4 1.1
Inhibition of formazan formation by female worms IC50 (μg/mL) 213.5 67.87 35.65 125.30 37.36 162.70 125.30 37.79 37.36
CC50 (μg/mL) 375 93.75 93.75 93.73 46.88 93.75 93.75 46.88 46.88
SI 1.8 1.4 2.6 0.75 1.3 0.6 0.7 1.2 1.3
Inhibition of mf motility IC50 (μg/mL) 154.8 62.50 125.0 31.25 55.61 62.50 31.25 31.25 125.0
CC50 (μg/mL) 375 93.75 93.75 93.73 46.88 93.75 93.75 46.88 46.88
SI 2.4 1.5 2.9 3.0 1.5 1.7 1.5 1.5 1.5