Table 5 The results of stratified meta-analysis
Subgroups | Acquisition memory | Retention memory | ||||||
|---|---|---|---|---|---|---|---|---|
Studies | Participants | Effect size [95 % CI] | Subgroup differences | Dtudies | Participants | Effect size [95 % CI] | Subgroup differences | |
Animal species | ||||||||
APP mice | 11 | 349 | −1.84 [−2.62, −1.05] | P = 0.0002 | 4 | 144 | 2.84 [1.35, 4.32] | P < 0.00001 |
Balb/c mice | 5 | 124 | −0.45 [−0.80, −0.09] | |||||
Kunming mice | 5 | 98 | −0.84 [−1.27, −0.42] | 3 | 60 | 1.12 [0.56, 1.67] | ||
SMP8 mice | 6 | 120 | −0.79 [−1.17, −0.41] | 6 | 120 | 1.36 [0.95, 1.77] | ||
SD rats | 9 | 208 | −2.78 [−4.06, −1.51] | 2 | 48 | 3.60 [2.63, 4.57] | ||
Wistar rats | 3 | 105 | −1.35 [−1.17, −0.41] | |||||
Sex | ||||||||
Male | 20 | 471 | −1.59 [−2.12, −1.06] | P < 0.00001 | 8 | 168 | 1.61 [1.17, 2.45] | P = 0.65 |
Female | 5 | 124 | −0.45 [−0.80, −0.09] | |||||
Female & Male | 14 | 409 | −1.68 [−2.31, −1.05] | 7 | 204 | 2.06 [1.15, 2.98] | ||
Model | ||||||||
Untransgenic | 22 | 535 | −1.46 [−1.94, −0.98] | P = 0.99 | 5 | 108 | 1.98 [0.88,3.08] | P = 0.93 |
Transgenic | 17 | 469 | −1.46 [−2.00, −0.91] | 10 | 264 | 1.92 [1.28, 2.56] | ||
Dose | ||||||||
Less 100 mg | 21 | 582 | −1.92 [−2.52, −1.32] | P = 0.04 | 8 | 216 | 2.23 [1.34, 3.11] | P = 0.15 |
100 mg | 11 | 270 | −0.91 [−1.37, −0.45] | 3 | 60 | 1.25 [0.69, 1.82] | ||
200 mg | 2 | 64 | 0.92 [−1.46, −0.39] | |||||
300 mg | 4 | 88 | −1.01 [−1.46, −0.56] | 4 | 96 | 1.98 [0.92, 3.05] | ||
Quality | ||||||||
4 | 2 | 60 | −2.10 [−5.27, −1.08] | P < 0.00001 | 1 | 12 | 3.86 [1.66, 6.05] | P = 0.006 |
5 | 15 | 361 | −1.26 [−1.64, −0.81] | 6 | 120 | 1.15 [0.76, 1.55] | ||
6 | 15 | 387 | −0.63 [−0.83, −0.42] | 3 | 60 | 1.56 [0.96, 2.16] | ||
7 | 7 | 196 | −3.82 [−4.41, −3.23] | 5 | 180 | 2.97 [1.71, 4.22] | ||