Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model

Table 1 Expressions of various neurotransmitters, including the frontal cortex, striatum and hippocampus of brain, in mice

Brain Cortex	Treatment	Neurotransmitter (ng/g brain tissue)
Brain Cortex	Treatment	DA	DOPAC	5HT	5HIAA	Norepinephrine
Frontal Cortex	Control	1277.7 ± 332.8^b	741.7 ± 115.5^b	797.3 ± 72.8^a	863.0 ± 47.2^a	409.1 ± 107.3^c
	STZ-PBS	238.4 ± 27.00.2^b	175.9 ± 55.5^c	323.3 ± 93.4^c	99.7 ± 11.5^c	685.6.9 ± 34.4^b
	STZ-Rosi	851.5 ± 307.3^b	615.3 ± 54.2^b	594.5 ± 220.3^bc	283.7 ± 39.9^b	939.2 ± 81.8^a
	STZ-OFE	2343.2 ± 824.4^a	1467.4 ± 136.6^a	931.1 ± 45.6^a	939.5.7 ± 59.8^a	861.33 ± 84.4^a
Striatum	Control	986.8 ± 73.2^b	1013.1 ± 101.6^ab	936.7 ± 93.8^a	863.0.0 ± 47.2^b	916.52 ± 49.9^a
	STZ-PBS	806.1 ± 138.3 ^b	681.6 ± 61.2^c	583.1 ± 97.4^b	481.0 ± 33.9^c	613.7 ± 26.2^b
	STZ-Rosi	1185.3 ± 423.9^b	797.6 ± 103.1^bc	613.8 ± 129.7^b	491.7 ± 20.2^c	731.8 ± 55.9^b
	STZ-OFE	2760.7 ± 323.0^a	1069.9 ± 120.8^a	693.2 ± 96.7^ab	716.7 ± 57.1^a	679.6 ± 65.7^b
Hippocampus	Control	288.5 ± 72.8^a	111.7 ± 30.5^b	1041.9 ± 103.6^b	1040.7 ± 71.6^a	257.6 ± 63.9^c
	STZ-PBS	84.6 ± 5.1^bc	129.0 ± 46.9^b	620.2 ± 66.2^c	219.0 ± 5.9^b	423.5 ± 85.8^bc
	STZ-Rosi	19.9 ± 6.2^c	49.1 ± 28.0^bc	864.3 ± 41.0^b	185.4 ± 63.2^b	702.9 ± 12.1^a
	STZ-OFE	255.1 ± 56.3^a	317.4 ± 121.3^a	1622.7 ± 83.0^a	280.8 ± 61.5^b	592.2 ± 107.9^ab

DA: dopamine; DOPAC: 3,4-dihydroxy phenlactic acid; 5-HT: 5-hydroxytryptamine; 5-H1AA: 5-hydroxy indole acetic acid. One way ANOVA followed by Tukey’s post hoc test was performed for multiple comparisons. Means in a row with different superscripts, such as ^a, ^b, ^c, ^ab, ^bc, is significantly different (p <= 0.05). Values are present as mean ± SEM, n = 6 in control group and n = 8 in the ogher groups