Fig. 5

The effect of curcumin on anti-inflammation was mediated by SOCS-1. a The mRNA levels of SOCS-1 were detected by qRT-PCR. Curcumin pretreatment increased the transcription of SOCS-1. b The protein levels of SOCS-1 were detected by Western Blot at 6 and 12 h postinduction. Curcumin pretreatment increased the protein level of SOCS-1. c The total STAT1 proteins and p-STAT1 were detected by Western Blot. The level of p-STAT1 was declined with curcumin treatment. d The mRNA levels of STAT1 were detected by qRT-PCR. Curcumin pretreatment suppressed the transcription of STAT1