Treatments | Dose (mg/kg) | Behavioural seizures | Mortality | ||||
---|---|---|---|---|---|---|---|
 |  | Onset (min) | Duration (min) | Number of motor seizures |  | ||
 |  | Tonus | Clonus | Tonus | Clonus |  |  |
Vehicle + Saline | – + – | – | – | – | – | – | – |
Vehicle + Bic | – + 2.7 | 2.35 ± 0.21 | 6.15 ± 1.12 | 5.32 ± 1.47 | 69.32 ± 1.38 | 24.16 ± 1.14 | 8/8 |
IGEFA + Bic | 15 + 2.7 | 4.12 ± 0.27 | 11.16 ± 1.13 | 4.21 ± 1.15 | 19.12 ± 1.54* | 14.57 ± 1.26 | 1/8*** |
IGEFA + Bic | 30 + 2.7 | 6.15 ± 1.26* | 13.53 ± 1.04* | 3.49 ± 1.26 | 16.35 ± 1.29* | 12.32 ± 1.39* | 1/8*** |
IGEFA + Bic | 60 + 2.7 | 7.21 ± 1.23* | 16.17 ± 1.18* | 3.15 ± 1.13 | 12.49 ± 1.17* | 11.49 ± 1.81* | 0/8*** |
IGEFA + Bic | 90 + 2.7 | 7.49 ± 1.49* | 18.32 ± 1.36* | 2.34 ± 1.52* | 11.26 ± 1.27** | 11.52 ± 1.16* | 0/8*** |
Diazepam + Bic | 5 + 2.7 | 8.27 ± 1.28** | 21.42 ± 2.19** | 1.26 ± 1.24* | 11.32 ± 1.45** | 10.26 ± 1.28* | 0/8*** |